Resistant Hypertension: A Real Entity Requiring Special Treatment?
Aug 01, 2016
Overview:The concept of resistant hypertension (RH) has received great attention in the past years, mainly as a possible target population for innovative therapeutic strategies. An increasing number of original articles and commentaries have focused on the clinical significance, prognosis and... more
Efficacy of β blockers in patients with heart failure plus atrial fibrillation: an individual-patient data meta-analysis
Oct 12, 2014
Overview: Background and knowledge gap According to current guidelines, a rhythm-control strategy (including pharmacological or electrical cardioversion) in patients with chronic HF, has not been demonstrated to be superior to a rate-control strategy in reducing mortality or morbidity. Preference of... more
Women with Stable Angina Pectoris and No Obstructive Coronary Artery Disease: Closer to a Diagnosis
Nov 15, 2018
Overview: Women have for many years been regarded as being at relatively low risk for the development of ischaemic heart disease (IHD).1,2 Recently this pattern has changed and cardiovascular disease (CVD) is now the leading cause of death for women in... more
Using DOACs In Patients With AF: Assessment, Monitoring And Treatment Reversal
Apr 05, 2018
Overview:Atrial fibrillation (AF) is the most commonly encountered arrhythmia in clinical practice in Western countries. The prevalence of AF depends on the population studied1 and especially on age.2–9 It is affected by increasing longevity and is modulated by the prevalence of cardiovascular... more
A Pilot Project of Familial Screening in Patients with Bicuspid Aortic Valve Disease
Jul 15, 2013
Overview:Background BAV is a risk factor for aortic valve disease in adults. It may be the most common cardiovascular malformation, with an estimated incidence of 0.6% to 1.36%. Previous studies attempted to investigate the hypothesis that clinically asymptomatic BAV may... more
Out-of-hospital administration of IV glucose-insulin-potassium in patients with suspected ACS: the IMMEDIATE trial
Jun 18, 2012
Overview:The authors investigated whether the immediate intravenous (IV) administration of glucose, insulin and potassium (GIK) in the setting of emergency medical services would reduce ischemia-related arrhythmias and myocardial injury in suspected acute coronary syndromes. Compared with placebo, GIK administration was... more
Sodium–Glucose Cotransporter 2 Inhibitors In Heart Failure
Nov 01, 2020
Overview:Potential Mechanisms Of Action, Adverse Effects And Future Developments Type 2 diabetes (T2D) remains a major cardiovascular (CV) risk factor1–5 and it confers an approximately two- to threefold fold excess risk for coronary heart disease, including MI, stroke and heart... more
Chest pain in aortic stenosis: novel diagnostic and therapeutic data
Jul 25, 2017
Overview:By Dennis Cokkinos Angina pectoris (AP) in aortic stenosis (AS) is not unusual. It can be seen in up to 75% of patients. It is associated with coronary artery disease (CAD) in 50-74% of patients; it’s for diagnosing CAD sensitivity... more
Antiplatelet Therapy In Acute Coronary Syndrome
Oct 10, 2018
Overview: Acute coronary syndrome (ACS) is a term used to encompass unstable angina (UA) and myocardial infarction (MI) with or without electrocardiographic (ECG) evidence of ST-segment elevation. Antiplatelet therapy has formed the backbone of ACS management for decades and the... more
Losartan versus candesartan in HF
Jun 18, 2012
Overview:Association of treatment with losartan vs candesartan and mortality among patients with heart failure In the present study the authors asked whether losartan use is associated with increased all-cause mortality in heart failure (HF) patients compared with candesartan. Among patients... more