The Role Of Inflammation In Diabetes: Current Concepts And Future Perspectives
Feb 08, 2021
Overview:Diabetes is a multifaceted metabolic disorder affecting the glucose status of the human body. Impaired glucose tolerance and hyperglycaemia are the main clinical and diagnostic features and the result of an absolute or relative insulin deficiency or resistance to its... more
Trimetazidine and Other Metabolic Modifiers
Jul 22, 2020
Overview:Although cardiovascular mortality has declined progressively in developed countries, ischaemic heart disease (IHD) and chronic stable angina cause a worse prognosis and poor quality of life and can dramatically increase healthcare costs.1–4 Traditionally, chronic stable angina has been interpreted as reversible... more
Cardiovascular Management of Adults with Marfan Syndrome
May 09, 2018
Overview: Marfan syndrome (MFS) is a disease in which connective tissue becomes weak secondary to fibrillin-1 mutations, resulting in aortic dilatation, aneurysm formation, aortic dissection, aortic regurgitation and mitral valve prolapse (MVP; see Table 1). Epidemiology MFS is an autosomal dominant... more
Key Recent Advances In Atherosclerosis Treatment With Modern Lipid-Lowering Drugs: The New Frontier With PCSK9 Inhibitors
Jan 04, 2019
Overview:Hypercholesterolemia has been known for several years to be a major risk factor in the development of atherosclerosis and consecutively cardiovascular disease. This epidemiological concept has been widely confirmed using different strategies that have reduced low-density lipoprotein (LDL) levels and... more
Left Ventricular Remodelling: A Problem In Search Of Solutions
Mar 01, 2018
Overview: The term cardiac remodelling (REM) is used to define changes that produce geometrical rearrangement of the normal structures of the heart, together with complex biological and molecular alterations. REM affects the heart at the level of the cardiomyocyte, the... more
Coronary Artery Spasm And Perivascular Adipose Tissue Inflammation: Insights From Translational Imaging Research
Aug 24, 2020
Overview:Coronary Artery Spasm and Adventitial Inflammation Coronary artery spasm plays an important role in the pathogenesis of a wide range of ischaemic heart disease, not only in variant angina, but also in other forms of angina pectoris and myocardial infarction.1,2 Recent... more
Dilatation of the Remaining Aorta After Aortic Valve or Aortic Root Replacement in Patients With Bicuspid Aortic Valve: A 5-Year Follow-Up
Aug 16, 2013
Overview:Background Bicuspid aortic valve (BAV) is the underlying pathology in as many as 1/3 of patients who undergo aortic valve replacement (AVR). It is now widely accepted that an inherent aortopathy exists independent of functional valvular pathology in many patients... more
Percutaneous Coronary Intervention Versus Optimal Medical Therapy for Prevention of Spontaneous Myocardial Infarction in Subjects With Stable Ischemic Heart Disease
Jul 09, 2013
Overview:Background CAD is the leading cause of death worldwide, contributing to over 7.2 million deaths annually. Early revascularization has been well validated to show a reduction in cardiovascular events in the management of ST segment elevation MI1-3. In addition, revascularisation... more
FDA approves label changes to include intestinal problems (sprue-like enteropathy) linked to blood pressure medicine olmesartan medoxomil
Apr 28, 2017
Overview:By : Dimitrios Tziakas, MD,PhD, Georgios Chalikias, MD,PhD The US Food and Drug Administration (FDA) has recently ( July 2013) issued a safety announcement that the blood pressure drug olmesartan medoxomil can cause intestinal problems known as sprue-like enteropathy... more
Qsymia Offers ‘Really Effective’ Weight Loss
Apr 28, 2017
Overview:By Professor Juan Tamargo, Madrid, Spain Qsymia is a formulation of two off-patent drugs already on the market: immediate-release phentermine and controlled-release topiramate. Phentermine is an amphetamine-like compound, currently licensed as a short-term weight loss agent due to its central... more